1: Barkov's Forces (Call of Duty: Modern Warfare 2019)
Usually, villains in Call of Duty involve WW2 German soldiers, Imperial Japanese soldiers and occasionally Cold War era Soviet Union soldiers, which by now are all dead and they post threat to no one in modern society, and the villains in classic Modern Warfare trilogies' were so over the top that you wouldn't take them seriously.
However, the portrayal of Russian soldiers as basically Space Nazis with Russian flags who murder civilians back-and-forth in Modern Warfare 2019 turns out to be suprisingly accurate, as this was made before Russo-Ukraine War even happened. The developers have effectively unknowingly predicted the future and created the most accurate portrayal of Russian soldiers in gaming history. Also, MW2019 eschews most dramatic setpieces in exchange for realistic battles, stealth mission and even letting you to play as a literal kid under Russian forces' annexation, which also makes the evils of Russian soldiers even more unnerving.
Moreover, unlike Makarov's group, who were so over-the-top that you would treat them as nothing more than supervillains that belong to Batman, Roman Barkov is a realistic ultranationalistic warlord with zero charisma and pure intimidation, who instigates annexation of other countries in the name of Russia's national security, a realistic motivation that eeriely sounds like something that Vladimir Putin would say to justify annexation of other countries.
2: Tubarov Bilmon (Mobile Suit Gundam Wing)
The Gundam equivalent of a Tech Bro Oligarch. Tubarov essentially invented the concept of drone warfare and military AI weaponry. Although military Mobile Suits don't exist in real life, drone warfare certainly does exist in real life.
With the rise of unmanned weapons and drones slowly phasing out humanity in war, we develop a habit of dehumanising enemies and treating war as nothing more than a game of racking up a scoreboard. Gone is the day where war would cost blood and sweat of like-minded warriors, there is no more heroic goal of fighting a war, or to hold respect to the fallen. Machines never think, they never tire, and they have no mercy, the perfect tool to wage war if you only see war as just a game.
Tubarov is the perfect representation of people obsessed with making automated weaponry to replace human factor and phasing out the sense of humanity in war, he cares nothing but his creation and how AI could become effective, regardless of the wellbeings of anyone.
3: Izanario Fareed (Iron-Blooded Orphans)
Gundam series is mainly known for geopolitical conflicts and wars involving Mobile Suit battles, over-the-top superweapons, Newtype shenanigans, continetal genocides, cycles of revenge and even drone warfare, or in Iron-Blooded Orphans' case, gang battles and mechanical monsters.
Usually, these kinds of things are far removed from our daily life if you don't live inside an active warzone or a region controlled by mafia gangsters. However, Izanario Fareed stands out for being a realistic evil that can happen in daily life in the form of a Space Epstein, a rich and untouchable person who routinely adopts children just to abuse them, with McGillis being one of his victims while Carta was completely oblivious to McGillis' upbringing. And in the end, Izanario gets away with it quite easily, much like most rich people who conduct these kinds of exploitation.
4: Stampa Halloi (Mobile Suit Gundam ZZ)
The Universal Century predecessor of Izanario. He is a rich and influential person who becomes the de-facto ruler of a space colony. Not only does he live a lavish life of having his own Mobile Suit collection in his own palace, he also routinely locks up women and adds them to his own harem.
5: Don Corneo (Final Fantasy 7)
The Final Fantasy equivalent of Stampa. He is a rich person who controls a slum, along with being a perverted crime boss. In a world threatened by supernatural threats and a veteran swordsman with a deep connection with an alien, it is a perverted crime boss that is more detestable.
6: Chief Irons (Resident Evil 2)
A corrupted police chief who takes the bribe from Umbrella to prevent anyone from investigating Umbrella's underground lab and uses the opportunity of zombie outbreak to exact his desire as a serial killer, murdering women and wildlife just to turn them into taxidermy specimen and display them in his office as his personal collection.
You are not likely to encounter zombies and medical companies that would develop over-the-top bioweapons and giant monsters in real life, but corrupted police officers and serial killers exist in real life, and those kinds of evil have no excuses other than selfishness, greed and lust for blood.
7: Billy Kincaid (Spawn)
In a superhero comic populated by literal demons and supernatural threats, Billy Kincaid is the most unnervingly evil villain. He is a serial killer who preys on children. He runs an ice cream store just so he can kidnap and murder children, a threat that can exist in real life.
You aren't likely to encounter literal demons if you don't work as a priest or something, but the fear of people losing their children in the hands of serial killers exists in real life.