r/Hematology • u/Then-Veterinarian696 • 10h ago
r/Hematology • u/helpingmysister3 • Nov 30 '25
Looking for survivors with MECOM-rearranged / complex karyotype AML (monosomy 5 & 7, persistent disease after 2 stem cell transplants). Please help me find them.
Hi everyone,
I’m reaching out because my sister is fighting for her life, and we’ve reached the point where every piece of information, every connection, and every survivor story might make a real difference.
My sister is 22 and has a very rare, extremely high-risk form of acute myeloid leukemia. Her cytogenetics include:
- MECOM (3q26/21) involvement
- Monosomy 5 and 7 (and also monosomy 1)
- Complex karyotype
- NPM1-, FLT3-
She relapsed early after her first allogeneic stem cell transplant (unrelated donor, Jan 2025). She then underwent a second allo transplant using my stem cells.
Despite everything, she still has 12–14% blasts, and she’s also fighting a disseminated fungal infection (Mucor + Aspergillus). Immunosuppression is being tapered to try to induce graft-versus-leukemia. She’s in a very fragile and dangerous situation.
I know that her subtype is one of the toughest in AML. But I also know there are rare survivors out there — people with MECOM-rearranged AML, inv(3)/t(3;3) AML, and those with monosomy 5/7 + complex karyotype who managed to beat the odds. Even a handful of these cases exist, and I’m trying to find them.
I’m asking for help with two things:
- If you or someone in your family survived AML with similar genetics (MECOM-rearranged, inv(3)/t(3;3), monosomy 7/5, complex karyotype), I would be incredibly grateful to speak to you. I want to understand what treatments worked, which centers helped, and what gave you a fighting chance.
- Please help share this post — in leukemia groups, Facebook communities, Discord servers, anywhere. This cancer subtype is so rare that the only way to find survivors is through human networks.
I’m not looking for miracle cures. I just want to learn from people who succeeded against similar odds. Even one message from someone who has been through this could help me point her doctors toward something they haven’t tried yet.
If you know anyone who might be connected to cases like this, please forward this post to them.
If you’re comfortable reaching out privately, please message me directly.
Thank you to everyone reading this — even if you can’t help directly, sharing this could genuinely save her life.
r/Hematology • u/Ok-Scallion-3461 • Apr 26 '25
Which Hematology Books Would You Recommend?
Hello everybody I am currently a resident in medical biology, working in the hematology department. I would like to have your opinion on which books to study. Given the large number of available books, which one would you recommend? Thank you!
r/Hematology • u/ScorpscorpioX • 1d ago
Staghorn megakaryocyte/seen in essential thrombocythemia
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r/Hematology • u/Realistic-Motor-495 • 2d ago
Discussion Hematology app is growing for you! Your input is more then welcome
clinicheckapp.comProgress on the Hematology app continues!
We are working on custom sounds and more features and would love to get an early input from you.
Your feedback helps shape the app development. Let us know what you think, what you’d like to see next. Comment this post with a feature that you would like to see soon.
Thank you!
r/Hematology • u/Realistic-Motor-495 • 2d ago
Discussion Hematology app is growing for you! Your input is more then welcome
clinicheckapp.comProgress on the Hematology app continues!
We are working on custom sounds and more features and would love to get an early input from you.
Your feedback helps shape the app development. Let us know what you think, what you’d like to see next. Comment this post with a feature that you would like to see soon.
Thank you!
r/Hematology • u/Waywoah • 4d ago
Question Odd looking inclusion in this monocyte?
From an abnormal diff coming from one of the local hospitals. I’m a student and this is for training, so I don’t have any other info unfortunately.
My professor didn’t recognize it either, but after searching guessed it was likely a consumed, but not “digested” RBC (or platelet? can’t remember which she mentioned now)?
r/Hematology • u/majesticgix • 4d ago
Alguem pra ajudar com essas células em liquido ascitico?
r/Hematology • u/Massive-Average-1784 • 4d ago
PATIENT NOT FOR DIAGNOSIS
Was referred to see a hematologist then got scheduled to a cancer center. Are hematologists available in other practices?
r/Hematology • u/No-Dinner-6005 • 8d ago
Question Reactive Lymphocytes?
I received a request to perform this peripheral blood smear for suspected lymphoma. The internal medicine department told me that the patient presents with: weight loss, night sweats, and lymphadenopathy.
Looking at the peripheral smear, I reported these cells as reactive lymphocytes; I don't believe this is a lymphoma, at least based on the morphology of these lymphocytes.
What do you think?
r/Hematology • u/_TheEighthHorcrux_ • 8d ago
Question What are these?
I'm looking at bat blood smears and I keep seeing these dark purple things. They look like bare nuclei of leukocytes with no cytoplasm. Does anyone know what they are?
Thanks for any helpful information.
r/Hematology • u/AKing727 • 10d ago
Best BMT / Cellular Therapy Clinical Textbook
I know there are posts on best hematology textbooks but are there any really good books on transplant and cellular therapy? I'm familiar with eh EBMT handbook but wondering if there are any others. I am a new PA that just started in BMT and want a good resource to read and reference. Thanks!
r/Hematology • u/jpverast • 11d ago
Which hematology book should I buy?
I'm looking to buy a hematology textbook and I'm torn between Williams Hematology and Wintrobe's Clinical Hematology.
For those who have used both, which one would you recommend and why? I'd love to hear your thoughts on their strengths and weaknesses, especially in terms of depth, readability, and usefulness for clinical practice.
Thanks!
r/Hematology • u/Ok_University_868 • 13d ago
Drépanocytose - Hématologie - Édition professionnelle du Manuel MSD
r/Hematology • u/Available_Yellow2273 • 15d ago
Discussion Recent changes can help you be more productive! We need your input
Progress on the Hematology app continues!
In this week we are glad to introduce support for iPhone DUO, bringing you more flexibility in your daily workflow.
We are also working on custom sounds and would love to share an early preview with you.
Your feedback helps shape the app development. Let us know what you think, what you’d like to see next, and what features are still missing.
Thank you!
r/Hematology • u/ScorpscorpioX • 18d ago
Prostatic ca Mets to bone marrow
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r/Hematology • u/SignificantSpell4720 • 20d ago
[PLEASE FILL OUT] Sickle Cell Anemia Pain Management Survey : BME Senior Design Project
We're a senior biomedical engineering design team, and we're exploring how well the current tools for managing sickle cell pain and inflammation at home work for patients, and where there's room for improvement. Our goal is to design a device or product that helps reduce pain at home without relying on drugs. Before we design anything, we want to hear from the people who actually live with this, so our work is based on real needs rather than assumptions.
Sickle Cell Anemia Patient Survey
About the survey:
- Takes about 5-10 minutes
- Please answer based on your own experience
- All responses are confidential
r/Hematology • u/ScorpscorpioX • 26d ago
Hairy cell
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r/Hematology • u/Ill-Combination-6801 • Sep 24 '26
Question elevated platelets in iron deficiency
Hi, I’m a nursing student & I wonder if it’s common for a patient to have persistently high/elevated platelets for 5-10 years due to iron deficiency? And would that not cause anemia eventually without any treatment?
note: this is just for education and not a personal example.
r/Hematology • u/SaltyEar7355 • Sep 24 '26
Congenital Methemoglobinemia
I would like to get in contact with anyone with knows anything about this condition. I’ve seen a few hematologists where the condition is so new to them, they don’t know anything about this. I’m getting frustrated and would love if someone out there knows more info about this or if you know of anyone who has this condition. Would appreciate it so much!
r/Hematology • u/ScorpscorpioX • Sep 18 '26
Interesting Find Bare or naked megakaryocyte nuclei
r/Hematology • u/NoGoose1890 • Sep 14 '26
OC My artist's impression of a peripheral blood slide from a septic individual
This is an my artistic impression of a peripheral blood smear taken from a patient with high-grade bacteremia and sepsis.
I just wanted to share my work and hear any thoughts about it cause, first time using Affinity Designer to create this watercolor painting! I have more in mind, but I'd love to hear any feedback about it!
r/Hematology • u/mildlyripenedmango • Sep 08 '26
Pathordle - a free new pathology diagnosis puzzle game!
Hello everyone! I am a current medical student who is interested in pathology, and a couple classmates and I came together to create this pathology puzzle game!
The game is very similar to Wordle and Doctordle. We have been fans of these puzzle games and thought it would be fun to have a "Pathordle" version where you start off with a pathology image and get additional clinical hints to figure out the diagnosis of the day. The goal is to figure out the diagnosis with the least number of hints possible!
I wanted to share it on here as we also include many cytology and blood smear-based puzzles I thought you may enjoy :)
We are not making any money from this website and our purpose for this game is to give medical students a way to practice their diagnostic skills and bring more attention to pathology. We would love to hear any feedback or suggestions and hope you will enjoy playing!
r/Hematology • u/Avidith • Sep 03 '26
Mixed cells in DLC
So in routine practice, differential leucocyte count is done via cell counters. N most clinics have 3-part counters. Means they can measure granulocytes, lymphocytes n mixed cells. Mixed cells are basically monocyte+basophil+eosinophil. Abbreviation is mid/mxd. Now how is the report given in your area of practice when 3-part analyser is used ? Any clinician pls respond. Also can any pathologist or lab physician or hematologist here enlighten me what are the guidelines for reporting dlc from 3-part analysers? N what is the common practice in your experience.
Lab technicians in my area are assuming basophil as 0 n then say if mid cells are 5%, they are writing eosinophils 3, monocytes 2 based on their mood. When I confronted them, they say that is what their seniors taught them. So I wanted to see how things r working in rest of the world n what are standard guidelines. I work in a relatively remote n low resource center of India with junior lab techs.
r/Hematology • u/Statesman6996 • Sep 01 '26
Abnormal RBC
Patient came on this morning with pretty bad labs. Sysmex threw up flags along side 6% IG so I did a smear review. What are these RBCs? I’ve asked a couple techs they told me could be my technique but I’ve never ran into this and couldn’t find any reference pics. Gonna send out to path but anyone have any idea?