I'm now 29 (M). When I was in my senior year of high school, around 2016, a mutual friend at a party told me about a new type of smokable drug being sold legally at a tobacco shop in Hollywood. He described it as something between weed and acid: a type of tobacco that got you significantly higher than marijuana, bordering on a psychedelic experience, with effects lasting only about 20 minutes.
Soon afterward, I went to the shop and bought some. It came in a small, transparent plastic screw-top container and contained a greenish, finely crumbled plant material that looked somewhat like weed but didn't smell like it.
I smoked it out of a regular weed bowl and immediately experienced an immense sensation of pleasure and sensory euphoria, far stronger than anything I'd experienced with marijuana. I didn't hallucinate, but everything became extraordinarily vibrant and vivid. Objects in the distance almost resembled a colorful pop-up book. The effects lasted approximately 20 minutes, just as my friend had described.
I remember my friend calling it "mullein," and I recall seeing the name "Green Mamba Dokha" associated with the product at the shop.
What followed was approximately 4–6 months of regularly buying and smoking this substance, multiple times a week, probably dozens of times in total. It was a dark period of my life, and I deeply regret it, particularly because I had no idea what I was actually consuming.
I've since learned that mullein leaves were sometimes used as a base for synthetic cannabinoid products. That same friend also told me sometime afterward that he'd discovered what we'd been smoking was actually K2/Spice. I largely ignored this at the time, perhaps out of denial. I can't independently verify exactly what the product contained, but I strongly suspect it was a synthetic cannabinoid.
Here's where my concern begins.
Around 2018, approximately 1–2 years after I stopped smoking this substance, I began developing what has since become extremely severe and debilitating OCD. Over the years, it's gradually gotten worse, with occasional periods of improvement followed by renewed deterioration. As of today, it's genuinely ruining my life.
My OCD primarily revolves around an overwhelming, constant fear of brain damage.
For years, I've regularly convinced myself that even the most minor physical events could cause a concussion or permanent neurological injury: driving over a pothole, tripping on a sidewalk, someone playfully slapping me, a car braking suddenly, or even moving my head too quickly. I've become afraid of running because I'm convinced that the repeated movement could somehow injure my brain.
Environmental pollutants are another enormous trigger. I'm constantly worried that I'm breathing in fumes, toxins, or gases that might be damaging my brain. The smell of paint terrifies me. Car exhaust, unfamiliar chemical odors, and even the possibility of mold can send me into intense periods of anxiety and obsessive rumination.
I also experience more conventional OCD symptoms, including excessive handwashing and repeatedly worrying about whether I've locked my door.
I cannot overstate how profoundly this condition has affected my life. I live in an almost constant state of fear, spending an enormous amount of mental energy obsessing over potential threats to my brain. I'm exhausted by the end of almost every day.
My family has spent an extraordinary amount of money trying to help me. I've undergone TMS, participated in a supervised psilocybin clinical trial at Yale specifically investigating OCD treatment, taken several psychiatric medications, and attended months of psychotherapy. Unfortunately, none of these interventions has produced meaningful, lasting improvement. I've been on prozac, trintellix and abilify for several years now.
My question is whether my history of suspected K2 use could have contributed to the development of this condition.
I understand that synthetic cannabinoids have been associated with serious psychiatric complications, including psychosis, anxiety, and cognitive disturbances. What I'm struggling to understand is whether repeated exposure during late adolescence could plausibly contribute to a severe psychiatric condition that develops a year or two after cessation and progressively worsens over many years.
I'm not claiming K2 necessarily caused my OCD. I'm aware that correlation doesn't establish causation, and I know OCD can develop independently of drug use. But given my history, I can't help wondering whether that period of synthetic cannabinoid use could have played some role.
Has anyone encountered research on this, experienced something similar, or worked clinically with patients who developed long-term psychiatric problems following synthetic cannabinoid use?
Any informed insight, particularly from people familiar with synthetic cannabinoids, psychiatry, or OCD, would be deeply appreciated.